Hyperthermia

Whole body hyperthermia operates on the principle that heating up the body’s core temperature will simulate a fever, tricking the body into thinking it is fighting an infection. This stimulates the immune system’s production and also enhances the functioning of the heart and blood vessels; the result is enhanced delivery of blood (and therefore oxygen, nutrients, and immune cells) to tissues. Whole body hyperthermia is a critical link in our program and is achieved at our clinic through far infrared energy.

There is also growing evidence that heat is directly detrimental to cancer cells. Many current chemotherapy protocols, for example, utilize heat to maximize the effectiveness of chemotherapeutic drugs in killing cancer cells.

Hyperthermia Evidence:

Fever-range whole- body thermal therapy combined with cisplatin, gemcitabine, and daily interferon-alpha: a description of a phase I-II protocol. Int J Hyperthermia. 2008 Dec;24(8):649-62. doi: 10.1080/02656730802104740.

Bull JM, Scott GL, Strebel FR, Nagle VL, Oliver D, Redwine M, Rowe RW, Ahn CW, Koch SM.

Effect of preoperative fever-range whole- body hyperthermia on immunological markers in patients undergoing colorectal cancer surgery.

Br J Anaesth. 2012 Nov;109(5):754-61. doi: 10.1093/bja/aes248. Epub 2012 Jul 31. Sulyok I, Fleischmann E, Stift A, Roth G, Lebherz-Eichinger D, Kasper D, Spittler A, Kimberger O.

Whole-body hyperthermia (WBH) in combination with carboplatin in patients with recurrent ovarian cancer – a phase II study.

Gynecol Oncol. 2009 Feb;112(2):384-8. doi: 10.1016/j.ygyno.2008.11.001. Epub 2008 Dec 6. Atmaca A, Al-Batran SE, Neumann A, Kolassa Y, Jäger D, Knuth A, Jäger E.

Preclinical and Clinical Aspects of Carboplatin and Gemcitabine Combined with Whole-body Hyperthermia for Pancreatic Adenocarcinoma. ANTICANCER RESEARCH 29:

3069-3078 (2009) AFSANEH BAKSHANDEH-BATH1, ANNE S. STOLTZ1, NILS HOMANN2, THOMAS WAGNER1, STEPHANIE ST.LTING1* and STEFAN O. PETERS1

A Systemic Hyperthermia Oncologic Working Group trial. Ifosfamide, carboplatin, and etoposide combined with 41.8 degrees C whole-body hyperthermia for metastatic soft tissue sarcoma. Oncology. 2003;64(4):312-21.Westermann AM, Wiedemann GJ, Jager

E, Jager D, Katschinski DM, Knuth A, Vörde Sive Vörding PZ, Van Dijk JD, Finet J, Neumann A, Longo W, Bakhshandeh A,Tiggelaar CL, Gillis W, Bailey H, Peters SO, Robins HI; Systemic Hyperthermia Oncologic Working Group.

Systemic hyperthermia and ICE chemotherapy for sarcoma patients: rationale and clinical status. Anticancer Res. 1997 Jul-Aug;17(4B):2899- 902. Wiedemann GJ, Robins HI, Katschinski DM, Mentzel M, D’Oleire F, Kutz M, Wagner T.

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